食品中新兴真菌毒素——链格孢毒素的生物合成调控研究进展

doi:10.12281/ffs2708-1893-20211102-006

未来食品科学 ›› 2022, Vol. 2 ›› Issue (3): 73-84.DOI: 10.12281/ffs2708-1893-20211102-006

食品中新兴真菌毒素——链格孢毒素的生物合成调控研究进展

孙帆，曹雪强，余佃贞，武爱波^*

中国科学院大学，中国科学院上海生命科学研究院上海营养与健康研究所中国科学院营养代谢与食品安全重点实验室，上海 200031

收稿日期:2021-11-02 修回日期:2022-03-11 接受日期:2022-09-15 出版日期:2022-11-04 发布日期:2022-10-13
通讯作者: 武爱波，E-mail：abwu@sibs.ac.cn
作者简介:第一作者简介：孙帆(1998—)（ORCID: 0000-0002-3019-5051），女，博士研究生，学士，研究方向为真菌毒素的生物合成和调控。 E-mail: sunfan2020@sibs.ac.cn *通信作者简介：武爱波(1977—)（ORCID: 0000-0002-7161-1592），男，研究员，博士，研究方向为食品安全与真菌毒素。 E-mail: abwu@sibs.ac.cn
基金资助:
上海市科技兴农技术创新项目(2019-02-08-00-02-F01145)

Research Progress in Biosynthetic Regulation of Alternaria Toxins, an Emerging Mycotoxin in Food

SUN Fan, CAO Xueqiang, YU Dianzhen, WU Aibo*

Chinese Academy of Sciences Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China

Received:2021-11-02 Revised:2022-03-11 Accepted:2022-09-15 Online:2022-11-04 Published:2022-10-13
Contact: WU Aibo，E-mail：abwu@sibs.ac.cn

摘要/Abstract

摘要： 链格孢菌（Alternaria）是全球范围内引起农作物病害的主要病原菌之一，其产生的链格孢毒素广泛分布于粮食、水果蔬菜等食品中，严重影响食品质量安全。本文主要介绍了动物毒性较强、研究较为深入的三大类非寄主专化型链格孢毒素：二苯并吡喃酮衍生物：交链孢酚（alternariol，AOH）、交链孢酚单甲醚（alternariol monomethyl ether，AME）、交链孢烯（altenuene，ALT）；苝衍生物：交链孢毒素（altertoxins-I/II/III，ATX-I/II/III）；四氨基酸衍生物：细交链孢菌酮酸（tenuazonic acid，TeA）。本文综述了近年来国内外主要链格孢毒素的生物合成和调控相关的研究进展，为食品中链格孢毒素污染的安全控制提供有价值的理论参考。

关键词: 链格孢毒素, 生物合成, 调控, 二苯并吡喃酮衍生物, 四氨基酸衍生物

Abstract: Alternaria genus is one of the major pathogens causing crop diseases in the world. Alternaria toxins produced are widely distributed in grain, fruits, vegetables, to seriously affect the quality and safety of foods. The most studied non-host-specific Alternaria toxins can be divided into three structural groups: dibenzopyrone derivatives (alternariol, alternariol monomethyl ether, altenuene), perylene derivatives (altertoxins I, II, III) and tetramic acid derivative (tenuazonic acid). Here, the research progress of Alternaria toxins biosynthesis and the regulation of Alternaria toxins production in recent years will be reviewed. This review will provide valuable theoretical references for the control of Alternaria toxins contamination in foods.

Key words: Alternaria toxins, biosynthesis, regulation, dibenzopyrone derivatives, tetramic acid derivative

中图分类号:

R155.3

孙帆, 曹雪强, 余佃贞, 武爱波. 食品中新兴真菌毒素——链格孢毒素的生物合成调控研究进展[J]. 未来食品科学, 2022, 2(3): 73-84.

SUN Fan, CAO Xueqiang, YU Dianzhen, WU Aibo. Research Progress in Biosynthetic Regulation of Alternaria Toxins, an Emerging Mycotoxin in Food[J]. Future Food Science, 2022, 2(3): 73-84.

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食品中新兴真菌毒素——链格孢毒素的生物合成调控研究进展

Research Progress in Biosynthetic Regulation of Alternaria Toxins, an Emerging Mycotoxin in Food

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