Future Food Science ›› 2021, Vol. 1 ›› Issue (4): 100-113.DOI: 10.12281/ffs2708-1893-20211011-008
FAN Zhuoyan1, LI Jingming1, YANG Xinquan2,*
Received:
2021-09-11
Revised:
2021-09-17
Accepted:
2021-09-30
Online:
2021-12-15
Published:
2021-10-15
Contact:
YANG Xinquan,Email:yangxq@gzhu.edu.cn
CLC Number:
FAN Zhuoyan, LI Jingming, YANG Xinquan. Underlying Mechanism of Dietary Anthocyantins in Prevention and Treatment of Alzheimer’s Disease[J]. Future Food Science, 2021, 1(4): 100-113.
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URL: https://ffs.gzhu.edu.cn/EN/10.12281/ffs2708-1893-20211011-008
[1]FERRUCCI L, REIRE M G, FABBRI E, et al. Measuring biological aging in humans: a quest[J]. Aging Cell, 2019, 19(2): 13080-13401. DOI:10.1111/acel.13080. [2]HOU Yujun, DAN Xiuli, BABBAR M, et al. Ageing as a risk factor for neurodegenerative disease[J]. Nature Reviews Neurology, 2019, 15(10): 565-581. DOI:10.1038/s41582-019-0244-7. [3]PIVTORAIKO V N, ROTH K A. Neurodegeneration: the molecular pathology of dementia and movement disorders[M]. 2nd ed. John Wiley and Sons Ltd, 2011. [4]NAZAM F, SHAIKH S, NAZAM N, et al. Molecular and cellular biochemistry mechanistic insights into the pathogenesis of neurodegenerative diseases: towards the development of effective therapy[J]. Molecular and Cellular Biochemistry, 2021, 476(7): 2739-2752. DOI:10.1007/s11010-021-04120-6. [5]AGOSTA F, GALANTUCCI S, FILIPPI M. Advanced magnetic resonance imaging of neurodegenerative diseases[J]. Neurological Sciences, 2017, 38(1): 41-51. DOI:10.1007/s10072-016-2764-x. [6]KAUR D, SHARMA V, DESHMUKH R. Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease[J]. Inflammopharmacology, 2019, 27(4): 663-677. DOI:10.1007/s10787-019-00580-x. [7]LI Ping, FENG Dou, YANG Dacheng, et al. Protective effects of anthocyanins on neurodegenerative diseases[J]. Trends in Food Science & Technology, 2021, 17(11):1-13. DOI:10.1016/j.tifs.2021.05.005. [8]Alzhimer’s Disease International. World Alzheimer Report 2010: the Global Economic Impact of Dementia\[R\]. Anders Wimo, Martin: Alzhimer’s Disease International, 2010. [9]杨青, 贾杰. 阿尔兹海默病相关指南及专家共识解读—全周期康复新视角[J]. 中国医刊, 2021, 56(1): 22-27. DOI:10.3969/j.issn.1008-1070.2021.01.007. [10]JIA Jianping, WEI Cuibai, CHEN Shuoqi, et al. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide[J]. Alzheimer’s and Dementia, 2018, 14(4): 483-491. DOI:10.1016/j.jalz.2017.12.006. [11]POJER E, MATTIVI F, JOHNSON D, et al. The case for anthocyanin consumption to promote human health: a review[J]. Comprehensive Reviews in Food Science & Food Safety, 2013, 12(5): 483-508. DOI:10.1111/1541-4337.12024. [12]CSEDAS G, LES F, GMEZ-SERRANILLOS M P, et al. Anthocyanin profile, antioxidant activity and enzyme inhibiting properties of blueberry and cranberry juices: a comparative study[J]. Food & Function, 2017, 8(11): 4187-4193. DOI:10.1039/c7fo01205e. [13]MATTIOLI R, FRANCIOSO A, MOSCA L, et al. Anthocyanins: a comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases[J]. Molecules, 2020, 25(17): 3809-3851. DOI:10.3390/molecules25173809. [14]ESRA S, ROGERS G T, BLUMBERG J B, et al. Long-term dietary flavonoid intake and risk of Alzheimer’s disease and related dementias in the Framingham Offspring Cohort[J]. The American Journal of Clinical Nutrition, 2020, 112(2): 343-353. DOI:10.1093/ajcn/nqaa079. [15]SHIH P H, CHAN Y C, LIAO J W, et al. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer’s disease[J]. Journal of Nutritional Biochemistry, 2010, 21(7): 598-605. DOI:10.1016/j.jnutbio.2009.03.008. [16]GUTIERRES J M, CARVALHO F B, SCHETINGER M, et al. Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats[J]. International Journal of Developmental Neuroscience, 2014, 33(1): 88-97. DOI:10.1016/j.ijdevneu.2013.12.006. [17]REHMAN S U, SHAH S A, ALI T, et al. Anthocyanins reversed D-galactose-induced oxidative stress and neuroinflammation mediated cognitive impairment in adult rats[J]. Molecular Neurobiology, 2017, 54(1): 255-271. DOI:10.1007/s12035-015-9604-5. [18]SONG Nan, YANG Hongpeng, PANG Wei, et al. Mulberry extracts alleviate Aβ25-35-induced injury and change the gene expression Pprofile in PC12 cells[J]. Evidence-based Complementary & Alternative Medicine (eCAM), 2014, 2014(1741-427X): 1-9. DOI:10.1155/2014/150617. [19]CLAUDINE, MANACH, GARY, et al. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies1,2,3[J]. American Journal of Clinical Nutrition, 2005, 81(1): 230-242. DOI:10.1021/jo070579k. [20]MCGHIE T K, WALTON M C. The bioavailability and absorption of anthocyanins: towards a better understanding[J]. Molecular Nutrition & Food Research, 2007, 51(6): 702-713. DOI:10.1002/mnfr.200700092. [21]TALAVRA S, FELGINES C, TEXIER O, et al. Anthocyanins are efficiently absorbed from the small intestine in rats[J]. Journal of Nutrition, 2004, 134(9): 2275-2279. DOI:10.1089/jmf.2004.7.381. [22]KAY C D. Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans[J]. Nutrition Research Reviews, 2006, 19(01): 137-146. DOI:10.1079/NRR2005116. [23]MIYAZAWA T, NAKAGAWA K, KUDO M, et al. Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans[J]. Journal of Agricultural & Food Chemistry, 1999, 47(3): 1083-1091. DOI:10.1021/jf9809582. [24]TENG Hui, CHEN Lei. Polyphenols and bioavailability: an update[J]. Critical Reviews in Food Science and Nutrition, 2019, 59(13): 2040-2051. DOI:10.1080/10408398.2018.1437023. [25]CRISTINA A L, BARBARA S H, GALLI R L, et al. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory[J]. Nutritional Neuroscience, 2005, 8(2): 111-120. DOI:10.1080/10284150500078117. [26]SVERINE T, CATHERINE F, ODILE T, et al. Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain[J]. Journal of Agricultural and Food Chemistry, 2005, 53(10): 3902-3908. DOI:10.1021/jf050145v. [27]PASSAMONTI S, VRHOVSEK U, VANZO A, et al. Fast access of some grape pigments to the brain[J]. Journal of Agricultural & Food Chemistry, 2005, 53(18): 7029-7034. DOI:10.1021/jf050565k. [28]FARIA A, PESTANA D, TEIXEIRA D, et al. Flavonoid transport across RBE4 cells: a blood-brain barrier model[J]. Cellular & Molecular Biology Letters, 2010, 15(2): 234-241. DOI:10.2478/s11658-010-0006-4. [29]YAMAKAWA M Y, UCHINO K, WATANABE Y, et al. Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer’s disease[J]. Nutritional Neuroscience, 2015, 19(1): 32-42. DOI:10.1179/1476830515Y.0000000042. [30]LIU Fufeng, ZHAO Fan, WANG Wenjuan, et al. Cyanidin-3-O-glucoside inhibits Aβ40 fibrillogenesis, disintegrates preformed fibrils, and reduces amyloid cytotoxicity[J]. Food & Function, 2020, 11(3): 1-47. DOI:10.1039/C9FO00316A. [31]RIVIRE C, RICHARD T, VITRAC X, et al. New polyphenols active on beta-amyloid aggregation[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18(2): 828-831. DOI:10.1016/j.bmcl.2007.11.028. [32]温海超. 矢车菊素-3-O-半乳糖苷改善阿尔兹海默病模型动物认知能力机制研究\[D\]. 北京: 中国农业大学, 2021:62-67. [33]TANIGUCHI S, SUZUKI N, MASUDA M, et al. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins[J]. Journal of Biological Chemistry, 2005, 280(9): 7614-7623. DOI:10.1074/jbc.M408714200. [34]HAN X, SHEN T, LOU H. Dietary polyphenols and their biological significance[J]. International Journal of Molecular Sciences, 2007, 8(9): 950-988. DOI:10.3390/i8090950. [35]QUINT H R, GALIGNIANA M D. The neuroregenerative mechanism mediated by the hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation[J]. 2015, 166(2): 637-649. DOI:10.1111/j.1476-5381.2011.01783.x. [36]QUINT H R, MASCHI D, GOMEZ-SANCHEZ C, et al. Subcellular rearrangement of hsp90‐binding immunophilins accompanies neuronal differentiation and neurite outgrowth[J]. Journal of Neurochemistry, 2010, 115(3): 716-734. DOI:10.1111/j.1471-4159.2010.06970.x. [37]HUNG T C, CHANG T T, FAN M J, et al. In silico insight into potent of anthocyanin regulation of FKBP52 to prevent Alzheimer’s Disease[J]. Evidence Based Complementary & Alternative Medicine Ecam, 2014, 2014:1-20. DOI:10.1155/2014/450592. [38]AVILA J, HERNNDEZ F. GSK-3 inhibitors for Alzheimer’s disease[J]. Expert Review of Neurotherapeutics, 2007, 7(11): 1527-1533. DOI:10.1586/14737175.7.11.1527. [39]GIESE K P. GSK-3: a key player in neurodegeneration and memory[J]. Iubmb Life, 2010, 61(5): 516-521. DOI:10.1002/iub.187. [40]PEI Jinjing J, EVA B, HEIKO B, et al. Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer’s disease neurofibrillary changes[J]. Journal of Neuropathology & Experimental Neurology, 1999, 58(9): 1010-1019. DOI:10.1097/00005072-199909000-00011. [41]ALI T, KIM M J, REHMAN S U, et al. Anthocyanin-loaded PEG-gold nanoparticles enhanced the neuroprotection of anthocyanins in an Aβ1-42 mouse model of Alzheimer’s Disease[J]. Molecular Neurobiology, 2017, 54(8): 6490-6506. DOI:10.1007/s12035-016-0136-4. [42]CALISSANO P, MATRONE C, AMADORO G. Apoptosis and in vitro Alzheimer’s disease neuronal models[J]. Communicative and Integrative Biology, 2009, 2(2): 163-169. DOI:10.4161/cib.7704. [43]LU Jun, WU Dongmei, ZHENG Yuanlin, et al. Purple sweet potato color alleviates D-galactose-induced brain aging in old mice by promoting survival of neurons via PI3K pathway and inhibiting cytochrome C-mediated apoptosis[J]. Brain Pathology, 2010, 20(3): 598-612. DOI:10.1111/j.1750-3639.2009.00339.x. [44]ULLAH I, PARK H Y, KIM M O. Anthocyanins protect against kainic acid-induced excitotoxicity and apoptosis via ROS-activated AMPK pathway in hippocampal neurons[J]. Cns Neuroscience & Therapeutics, 2014, 20(4): 327-338. DOI:10.1111/cns.12218. [45]WEN Haichao, CUI Hui, TIAN Hehe, et al. Isolation of neuroprotective anthocyanins from black chokeberry (Aronia melanocarpa) against amyloid-β-induced cognitive impairment[J]. Foods, 2020, 10(1): 63-77. DOI:10.3390/foods10010063. [46]DASKALOVA E, DELCHEV S, TOPOLOV M, et al. Aronia melanocarpa (Michx.) Elliot fruit juice reveals neuroprotective effect and improves cognitive and locomotor functions of aged rats[J]. Food and Chemical Toxicology, 2019, 132(2019): 110674-110702. DOI:10.1016/j.fct.2019.110674. [47]SUNG M K, CHUNG M J, HA T J, et al. Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids[J]. Life Sciences, 2012, 90(21-22): 874-882. DOI:10.1016/j.lfs.2012.04.025. [48]BADSHAH H, KIM T H, KIM M O. Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro[J]. Neurochemistry International, 2014, 80(2015): 51-59. DOI:10.1016/j.neuint.2014.10.009. [49]YOU Mingyao, CAI Yinhao, FAN Zhudi, et al. Protective effect of Cy-3G on PC12 cells against beta-amyloid-induced apoptosis and the possible mechanism[J]. International Journal of Clinical and Experimental Medicine, 2017, 10(3): 4565-4573. [50]BELKACEMI A, RAMASSAMY C, GHRIBI O. Anthocyanins protect SK-N-SH Cells against acrolein-induced toxicity by preserving the cellular redox state[J]. Journal of Alzheimer’s Disease, 2016, 50(4): 981-998. DOI:10.3233/JAD-150770. [51]MADORE C, YIN Z, LEIBOWITZ J, et al. Microglia, lifestyle stress, and neurodegeneration[J]. Immunity, 2020, 52(2): 222-240. DOI:10.1016/j.immuni.2019.12.003. [52]BISHT K, SHARMA K, TREMBLAY M . Chronic stress as a risk factor for Alzheimer’s disease: roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress[J]. Neurobiology of Stress, 2018, 9(2018): 9-21. DOI:10.1016/j.ynstr.2018.05.003. [53]KATSUMOTO A, TAKEUCHI H, TAKAHASHI K, et al. Microglia in Alzheimer’s disease: risk factors and inflammation[J]. Frontiers in neurology electronic resource, 2018, 9(2018): 978-985. DOI:10.3389/fneur.2018.00978. [54]PHAN T, MALKANI R. Sleep and circadian rhythm disruption and stress intersect in Alzheimer’s disease[J]. Neurobiology of Stress, 2018, 10(2019): 100133-100146. DOI:10.1016/j.ynstr.2018.10.001. [55]BAALMAN K, MARIN M A, HO S Y, et al. Axon initial segment-associated microglia[J]. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 2015, 35(5): 2283-2292. DOI:10.1523/JNEUROSCI.3751-14.2015. [56]SAVIC D, STOJILJKOVIC M, LAVRNJA I, et al. Ribavirin shows immunomodulatory effects on activated microglia[J]. Immunopharmacology and Immunotoxicology, 2014, 36(6): 433-441. DOI:10.3109/08923973.2014.971962. [57]CAREY A N, FISHER D R, RIMANDO A M, et al. Stilbenes and anthocyanins reduce stress signaling in BV-2 mouse microglia[J]. Journal of Agricultural & Food Chemistry, 2013, 61(25): 5979-5986. DOI:10.1021/jf400342g. [58]LI Jing, ZHAO Runtian, JIANG Yuhan, et al. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia[J]. Food & Function, 2020, 11(2): 1572-1584. DOI:10.1039/C9FO02103E. [59]MU Teng, GUAN Yang, CHEN Tianqiao, et al. Black raspberry anthocyanins protect BV2 microglia from LPS-induced inflammation through down-regulating NOX2/TXNIP/NLRP3 signaling[J]. Journal of Berry Research, 2021, 11(10): 1-15. DOI:10.3233/JBR-200692. [60]李建光, 阳莹, 刘倩芸, 等. 黑果小檗总花色苷对Aβ25-35诱导的AD小鼠及小胶质细胞神经炎性反应模型的影响[J]. 中华中医药杂志, 2017, 32(2): 424-427. DOI:CNKI:SUN:BXYY.0.2017-02-111. [61]雷洪涛, 王筠, 马淑骅, 等. IL-1β、TNF-α 与阿尔兹海默病的研究进展[J]. 中国老年学, 2014, 000(024): 7115-7117. DOI:10.3969/j.issn.1005-9202.2014.24.137. [62]TORO V C, TEHRANIAN R, ZETTERSTRM M, et al. Increased gene expression of interleukin-1α and interleukin-6 in rat primary glial cells induced by β-amyloid fragment[J]. Journal of Molecular Neuroscience, 2001, 17(3): 341-350. DOI:10.1385/JMN:17:3:341. [63]HAMBY M E, SOFRONIEW M V. Reactive astrocytes as therapeutic targets for CNS disorders[J]. Journal of the American Society for Experimental NeuroTherapeutics, 2010, 7(4): 494-506. DOI:10.1016/j.nurt.2010.07.003. [64]KHAN M S, ALI T, KIM M W, et al. Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex[J]. Neurochemistry International, 2016, 100(2016): 1-10. DOI:10.1016/j.neuint.2016.08.005. [65]ZHAN Xinhua, BORYANA S, SHARP F R. Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer’s disease brain: a review[J]. Frontiers in Aging Neuroscience, 2018, 42(10): 1-14. DOI:10.3389/fnagi.2018.00042. [66]RIEDER R, WISNIEWSKI P J, ALDERMAN B L, et al. Microbes and mental health: a review[J]. Brain Behavior & Immunity, 2017, 6(2017): 9-17. DOI:10.1016/j.bbi.2017.01.016. [67]CLARKE G, GRENHAM S, SCULLY P, et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner[J]. Molecular psychiatry, 2013, 18(6): 666-673. DOI:10.1038/mp.2012.77. [68]REA K, DINAN T G, CRYAN J F. The microbiome: a key regulator of stress and neuroinflammation[J]. Neurobiology of Stress, 2016, 4(C): 23-33. DOI:10.1016/j.ynstr.2016.03.001. [69]LYTE M, CRYAN J F. Microbial endocrinology: the microbiota-gut-brain axis in health and disease[M]. New York: Springer New York Heidelberg Dordrecht, 2014:1-440. DOI:10.1007/978-1-4939-0897-4_1. [70]LYTE M, MILLER V. Microbial endocrinology in the microbiome-gut-brain axis: how bacterial production and utilization of neurochemicals influence behavior[J]. Plos Pathogens, 2013, 9(11): 1003726-1003729. DOI:10.1371/journal.ppat.1003726. [71]CARDONA F, ANDRS-LACUEVA C, TULIPANI S, et al. Benefits of polyphenols on gut microbiota and implications in human health[J]. Journal of Nutritional Biochemistry, 2013, 24(8): 1415-1422. DOI:10.1016/j.jnutbio.2013.05.001. [72]KEPPLER K, Humpf H U. Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora[J]. Bioorganic and Medicinal Chemistry, 2005, 17(13): 5195-5205. DOI:10.1016/j.bmc.2005.05.003. [73]FARIA A, MEIRELES M, FERNANDES I, et al. Flavonoid metabolites transport across a human BBB model[J]. Food Chemistry, 2014, 149(2014): 190-196. DOI:10.1016/j.foodchem.2013.10.095. [74]TALAVERA S, FELGINES C, TEXIER O, et al. Anthocyanin metabolism in rats and their distribution to digestive area, kidney, and brain[J]. Journal of Agricultural and Food Chemistry, 2005, 53(10): 3902-3908. DOI:10.1021/jf050145v. [75]WANG Dongjie, LAP H, JEREMIAH F, et al. Role of intestinal microbiota in the generation of polyphenol‐derived phenolic acid mediated attenuation of Alzheimer’s disease β‐amyloid oligomerization[J]. Molecular Nutrition and Food Research, 2015, 59(6): 1025-1040. DOI:10.1002/mnfr.201400544. [76]JAEGER B N, PARYLAK S L, GAGE F H, et al. Mechanisms of dietary flflavonoid action in neuronal function and neuroinflflammation[J]. Molecular Aspects of Medicine, 2018, 61(2018): 50-62. DOI:10.1016/j.mam.2017.11.003. [77]CRYAN J F, O’RIORDAN K J, COWAN C, et al. The microbiota-gut-brain Axis[J]. Physiological Reviews, 2019, 99(4): 1877-2013. DOI:10.1152/physrev.00018.2018. [78]MANCUSO C, SANTANGELO R. Alzheimer’s disease and gut microbiota modifications: the long way between preclinical studies and clinical evidence[J]. Pharmacological Research, 2017, 129(2018): 329-336. DOI:10.1016/j.phrs.2017.12.009. [79]NAVIGLIO D. Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer’s disease[J]. Journal of Alzheimer’s disease: JAD, 2020, 78(2): 1-15. DOI:10.3233/JAD-200306. [80]OSORIO C, KANUKUNTL T, DIAZ E, et al. The post-amyloid ara in Alzheimer’s disease: trust your gut feeling[J]. Frontiers in Aging Neuroscience, 2019, 11(2019): 143-170. DOI:10.3389/fnagi.2019.00143. |
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